Domustyche Guest House

5 Via Sebastiano Grandis, Esquilino, Rome, Italy - Near popular attractions
9.4/10 · 124 reviews

The comfortable 4-star Domustyche Guest House Rome offers easy access to the erroneously named Temple of Minerva Medica, which is situated just 6 minutes' walk away.

Location

This Rome hotel boasts a prime location 2.1 miles from Borghese Gallery and Museum and 0.5 miles from National Museum of Musical Instruments. Basilica of St. Mary of the Angels and the Martyrs is also located approximately 25 minutes' walk from the guest house. Guests can also visit Scala Sancta Sanctuary, located a few moments from the Domustyche Guest House Rome. Flaminio train station is 2.3 miles away, and Manzoni metro station is 0.4 miles away.

Rooms

The rooms come with coffee and tea making facilities, as well as a flat-screen TV with satellite channels for guests' convenience. The bathrooms are equipped with a bidet, a separate toilet, and a shower, along with hairdryers and towels. The rooms also overlook the urban.

Food & Drinks

Domustyche Guest House is around 5 minutes by foot from Osteria La Sol Fa and offers a broad selection of meals.

Why choose Domustyche Guest House Rome

Select room

  • Air-conditioned family rooms available

  • Free WiFi throughout the property

  • Shared kitchen facilities for guests

  • Luggage storage available on site

Main amenities

  • Wi-Fi

  • Child-friendly

  • Air conditioning

  • No pets allowed

General
  • Wi-Fi
  • Child-friendly
  • Air conditioning
  • No pets allowed
1/10

Internet

  • Wi-Fi

Parking options

  • Parking

Property services

  • Security

In the kitchen

  • Shared kitchen
  • Electric kettle

For kids

  • Cots

In the rooms

  • Air conditioning
  • Heating

In the bathroom

  • Free toiletries

Devices

  • Flat-screen TV

General facilities

  • No smoking on site
  • Lift
  • Smoke detectors
  • Fire extinguishers
  • Key access

Pets

  • No pets allowed

Important information

Check-in:
from 14:00 until 22:00
Check-out:
until 10:00
License number35398,IT058091B45RY32CGL

Enter dates to see availability

From USD 163 per night
Check-in 20 Oct 2026
Check-out 21 Oct 2026
Guests 2 guests

Adults:

2

Children:

0
All rates verified
How we verified prices Our team regularly checks prices to make sure you see the lowest available rates. We compare them with hotel prices and other providers. If discounts or promotions appear, prices on our site are updated accordingly.

Rooms

Current offers Editor's Pick
Up to 15% off

Longer Stays

A few extra nights let you slow down, find favorite spots, and experience the place beyond the highlights.
5 nights or more Discount will be applied to your results
Up to 10% off

Mobile Rates

Book in a few taps and save a little more for the places, tastes, and moments waiting throughout your stay.
Book via mobile Includes special rates from Booking.com
Up to 20% off

Early Bird

Reserve while the right dates are open, then enjoy planning everything that comes after stress-free, step by step.
Book 30+ days ahead Some dates already include an extra discount

Photos of Domustyche Guest House Rome

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Domustyche Guest House
Domustyche Guest House
Domustyche Guest House
Domustyche Guest House

Domustyche Guest House Rome

Hotel providing modern amenities and access to city sites

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Domustyche Guest House

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Domustyche Guest house 4*
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Guest house Domustyche 4*
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Domustyche Guest house Rome
Domustyche Guest house
Domustyche Guest house Rome
Guest house Domustyche Rome
Guest house Domustyche Rome
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Domustyche Guest house 4*
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Domustyche Guest house 4*
Domustyche Guest house Rome
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Location of Domustyche Guest House Rome

5 Via Sebastiano Grandis, Esquilino, Rome, Italy

 -  Near popular attractions
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    Guest reviews of Domustyche Guest House Rome

    Based on ratings from trusted providers

    9.4 /10
    Superb 124 reviews
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          100% Verified Reviews
          Enter dates to see availability
          From USD 163 per night
          Check-in 20 Oct 2026
          Check-out 21 Oct 2026
          Guests 2 guests

          Adults:

          2

          Children:

          0
          All rates verified
          How we verified prices Our team regularly checks prices to make sure you see the lowest available rates. We compare them with hotel prices and other providers. If discounts or promotions appear, prices on our site are updated accordingly.
          Check-in & out
          20 Oct 2026
          —
          21 Oct 2026
          Guests
          2 guests
          Check availability
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          Important information
          Domustyche Guest House
          Check-in:
          from 14:00 until 22:00
          Check-out:
          until 10:00
          License number35398,IT058091B45RY32CGL